CR Mimetic Longevity Formula

In 2003, the Life Extension Foundation® introduced a standardized extract of resveratrol, a natural compound shown to favorably alter genes implicated in the aging process—many of the same genes that respond to calorie restriction or CR. In 2009, we introduced pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your “longevity genes.” This year, we advanced the field even further, bringing together the 5 known calorie restriction mimetics in a single, high potency formula: resveratrol, pterostilbene, quercetin, grape seed polyphenols, and black tea extract.1-8 Now we announce the latest innovation in the science of longevity with new CR Mimetic Longevity Formula featuring fisetin. This little-known flavonoid is the sixth compound shown to simulate a similar youthful gene expression pattern as calorie restriction9—without significant dietary modification. In the most exciting development to date, this novel compound (fisetin) may also enhance the effects of resveratrol.10 Life Extension® has gone to extraordinary lengths to identify compounds that simulate calorie restriction’s ability to trigger youthful gene expression—the process by which genes transmit signals that slow certain aspects of aging. For example, previous research funded by Life Extension showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract induced many of the favorable gene expression changes observed in calorie-restricted animals. A comprehensive review of the scientific literature further revealed that certain compounds found in berries, such as pterostilbene, also possess potent “longevity gene” activators that work in synergy with resveratrol. Most abundant in strawberries, fisetin has the power to “switch on” powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.9 It also supports aging neurons in the presence of oxidative stress.11-13 Each serving of the new CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction’s favorable influence on your longevity genes. Most importantly, fisetin works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown10 and extending its effects. This new formula provides cutting-edge broad spectrum support for youthful gene expression from the most scientifically validated, natural sources.